ParkinsonCanadaV1, Main, Exploration, bibRecord, 000C16

Abnormal metabolic network activity in REM sleep behavior disorder

Identifieur interne : 000C16 ( Main/Exploration ); précédent : 000C15; suivant : 000C17

Abnormal metabolic network activity in REM sleep behavior disorder

Auteurs : Florian Holtbernd [États-Unis] ; Jean-François Gagnon [Canada] ; Ron B. Postuma [Canada] ; YILONG MA [États-Unis] ; Chris C. Tang [États-Unis] ; Andrew Feigin [États-Unis] ; Vijay Dhawan [États-Unis] ; Mélanie Vendette [Canada] ; Jean-Paul Soucy [Canada] ; David Eidelberg [États-Unis] ; Jacques Montplaisir [Canada]

Source :

Neurology [ 0028-3878 ] ; 2014.

RBID : Pascal:14-0077399

Descripteurs français

Pascal (Inist)
- Trouble du sommeil, Pathologie du système nerveux, Sommeil paradoxal, Comportement.

English descriptors

KwdEn :
- Aged, Behavior, Fluorodeoxyglucose F18, Follow-Up Studies, Humans, Lewy Body Disease (complications), Lewy Body Disease (metabolism), Middle Aged, Multimodal Imaging, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (metabolism), Positron-Emission Tomography, Predictive Value of Tests, REM Sleep Behavior Disorder (complications), REM Sleep Behavior Disorder (diagnosis), REM Sleep Behavior Disorder (metabolism), Rapid eye movement sleep, Single-Blind Method, Sleep disorder, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed.
MESH :
- chemical : Fluorodeoxyglucose F18.
- complications : Lewy Body Disease, Parkinson Disease, REM Sleep Behavior Disorder.
- diagnosis : REM Sleep Behavior Disorder.
- metabolism : Lewy Body Disease, Parkinson Disease, REM Sleep Behavior Disorder.
- Aged, Follow-Up Studies, Humans, Middle Aged, Multimodal Imaging, Positron-Emission Tomography, Predictive Value of Tests, Single-Blind Method, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed.

Abstract

Objective: To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion. Methods: For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with ¹⁸F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values. Results: PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r² = 0.64, p < 0.0001). Conclusions: Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963420

Affiliations:

Le document en format XML

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<idno type="ISSN">0028-3878</idno>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Behavior</term>
<term>Fluorodeoxyglucose F18</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Lewy Body Disease (complications)</term>
<term>Lewy Body Disease (metabolism)</term>
<term>Middle Aged</term>
<term>Multimodal Imaging</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Positron-Emission Tomography</term>
<term>Predictive Value of Tests</term>
<term>REM Sleep Behavior Disorder (complications)</term>
<term>REM Sleep Behavior Disorder (diagnosis)</term>
<term>REM Sleep Behavior Disorder (metabolism)</term>
<term>Rapid eye movement sleep</term>
<term>Single-Blind Method</term>
<term>Sleep disorder</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Fluorodeoxyglucose F18</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Lewy Body Disease</term>
<term>Parkinson Disease</term>
<term>REM Sleep Behavior Disorder</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>REM Sleep Behavior Disorder</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lewy Body Disease</term>
<term>Parkinson Disease</term>
<term>REM Sleep Behavior Disorder</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Multimodal Imaging</term>
<term>Positron-Emission Tomography</term>
<term>Predictive Value of Tests</term>
<term>Single-Blind Method</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Trouble du sommeil</term>
<term>Pathologie du   système nerveux</term>
<term>Sommeil paradoxal</term>
<term>Comportement</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion. Methods: For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with <sup>18</sup>
F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values. Results: PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r<sup>2</sup>
 = 0.64, p < 0.0001). Conclusions: Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Québec</li>
</region>
<settlement><li>Montréal</li>
</settlement>
<orgName><li>Université McGill</li>
<li>Université du Québec à Montréal</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Holtbernd, Florian" sort="Holtbernd, Florian" uniqKey="Holtbernd F" first="Florian" last="Holtbernd">Florian Holtbernd</name>
</noRegion>
<name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name>
<name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
<name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name>
<name sortKey="Tang, Chris C" sort="Tang, Chris C" uniqKey="Tang C" first="Chris C." last="Tang">Chris C. Tang</name>
<name sortKey="Yilong Ma" sort="Yilong Ma" uniqKey="Yilong Ma" last="Yilong Ma">YILONG MA</name>
</country>
<country name="Canada"><noRegion><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name>
</noRegion>
<name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name>
<name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name>
<name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name>
<name sortKey="Postuma, Ron B" sort="Postuma, Ron B" uniqKey="Postuma R" first="Ron B." last="Postuma">Ron B. Postuma</name>
<name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name>
<name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name>
<name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson au Canada (serveur d'exploration)

Abnormal metabolic network activity in REM sleep behavior disorder

Abnormal metabolic network activity in REM sleep behavior disorder

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	La maladie de Parkinson au Canada (serveur d'exploration)
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